Meta-analysis on the relationship between tobacco smoking, alcohol drinking and p53 alteration in cases with esophageal carcinoma / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship between tobacco smoking, drinking and p53 alteration in esophageal carcinoma.</p><p><b>METHODS</b>Literature on the relationship between p53 alteration in esophageal carcinoma and tobacco smoking, drinking through Meta-analysis were reviewed.</p><p><b>RESULTS</b>In 14 selected papers related to tobacco smoking, pooled odds ratio (OR) of tobacco smoking with P53 overexpression and p53 alteration were 1.99 (95% CI 1.30- 3.06) and 1.64 (95% CI 1.13 - 2.37), respectively (P < 0.05). Pooled OR of tobacco smoking with p53 mutation was 1.11 (95% CI 0.47 - 2.76) (P > 0.05). In 11 selected papers on alcohol drinking, pooled OR of drinking with P53 overexpression, p53 mutation and p53 alteration were 1.30 (95% CI 0.83 - 2.04), 1.13 (95% CI 0.67 - 1.90) and 1.22 (95% CI 0.87 - 1.72) respectively (P > 0.05).</p><p><b>CONCLUSION</b>There were significant relations between tobacco smoking and p53 alteration while there were no significant relations between alcohol drinking and p53 alteration.</p>