Significance of p53 gene mutation and P53 protein expression abnormality on the prognosis of esophageal cancer: a meta-analysis study / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 769-774, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-247478
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the prognostic significance of p53 mutation and P53 protein expression abnormality among esophageal cancer.</p><p><b>METHODS</b>The results of 27 random controlled trials from 1990 to 2003 were analyzed by meta-analysis method. The overall positive rate of p53 was 52.9% among the cumulative 2174 cases. Relative hazard (RH) was applied to evaluate the risk of disease and all data were analyzed by Dersimonian-Laird method.</p><p><b>RESULTS</b>The analysis for homogeneity (q statistics test) showed that all eligible studies were with heterogeneity (q = 59.88, P < 0.005). The combined RH was 2.07 and 95% confidence interval was 1.58-2.70.</p><p><b>CONCLUSION</b>Findings showed that p53 was a poor prognosis biomarker for esophageal cancer gene diagnosis but might benefit to the strategy of treatment.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Esophageal Neoplasms
/
Carcinoma, Squamous Cell
/
Genes, p53
/
Tumor Suppressor Protein p53
/
Genetics
/
Metabolism
/
Mutation
Type of study:
Prognostic study
/
Systematic reviews
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2004
Type:
Article
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