Protective effect of recombinant HMGB1 A box protein in mouse with acute hepatic failure / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 222-226, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-247553
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of recombinant HMGB1 A box protein in mouse with acute hepatic failure.</p><p><b>METHOD</b>Acute hepatic failure was induced by D-galactosamine and lipopolysaccharide in mice. After injection with saline (control) or recombinant HMGB1 A box proteins, the expression of HMGB1 in liver tissues was detected by immunohistochemistry and RT-PCR, and the serum TNFalpha and IL-1beta were quantified.</p><p><b>RESULTS</b>rHMGB1-Abox protein alleviated the acute liver damage. rHMGB1-Abox protein treatment decreased the expression of HMGB1 in liver tissues and reduced the serum levels of TNFalpha and IL-1beta.</p><p><b>CONCLUSION</b>rHMGB1-Abox protein can alleviate the acute liver damage and inhibit the expression of HMGB1.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recombinant Proteins
/
Tumor Necrosis Factor-alpha
/
Liver Failure, Acute
/
HMGB1 Protein
/
Therapeutic Uses
/
Interleukin-1beta
/
Genetics
/
Liver
/
Metabolism
/
Mice, Inbred Strains
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2010
Type:
Article
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