Phenylhexyl isothiocyanate (PHI) regulates histone methylation and acetylation and induces apoptosis in SMMC-7721 cells / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 209-212, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-247556
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of PHI on histone acetylation and methylation in hepatocellular carcinoma line SMMC-7721 cells.</p><p><b>METHODS</b>Apoptosis was measured by TUNNEL assay. Histone methylation and acetylation were detected by Western blot.</p><p><b>RESULTS</b>PHI inhibited cells growth and induced apoptosis. PHI treatment resulted in increased acetylation of histone H3 and H4 , elevated level of histone H3 lysine 4 methylation, and decreased level of histone H3 lysine 9 methylation.</p><p><b>CONCLUSIONS</b>PHI can modulate both histone acetylation and methylation, which could remodel chromatin structure. PHI may be a novel anticancer drug.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Acetylation
/
Histones
/
Apoptosis
/
Isothiocyanates
/
Cell Line, Tumor
/
Cell Proliferation
/
Metabolism
/
Methylation
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2010
Type:
Article
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