The reassessment of the diagnostic value of 24-hour urinary copper excretion in children with Wilson's disease / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 49-53, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-247602
ABSTRACT
<p><b>OBJECTIVE</b>To reassess the diagnostic value of 24 hour urinary copper excretion in children with Wilson disease (WD).</p><p><b>METHODS</b>From July 2005 to June 2007, inpatients over three years old in a pediatric liver center were assigned into WD and non-WD group.</p><p><b>RESULTS</b>94 patients, including 26 cases in WD and 68 in non-WD group, were enrolled in this study. The median of 24 h urinary copper excretion was 98.5 microg in WD group and 25.8 microg in the non-WD group (Z = -6.111, P equal to 0.000). The area under receiver operator curve (ROC) was 0.909 (95% CI 0.839-0.979, P equal to 0.000). The sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 84.6%, 91.2%, 89.4%, 78.6% and 93.9% respectively using 52.0 ug as a cutoff value, and 50.0%, 97.1%, 84.0%, 86.7% and 83.5% using 100 microg as a cutoff value. The goodness of fitness of 52 microg criteria was significantly higher than 100 microg criteria (kappacoefficient 0.760, 0.541 respectively, P equal to 0.000).</p><p><b>CONCLUSION</b>Comparing to 100, 52 microg of 24 h urinary copper excretion as a cutoff value significantly improves the sensitivity and accuracy for diagnosing WD in children.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Penicillamine
/
Time Factors
/
Urine
/
Ceruloplasmin
/
Predictive Value of Tests
/
ROC Curve
/
Sensitivity and Specificity
/
Age Factors
/
Copper
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS