The spontaneous YMDD mutation rate in chronic hepatitis B patients / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 887-890, 2009.
Article
in Zh
| WPRIM
| ID: wpr-247634
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the spontaneous YMDD mutation rate.</p><p><b>METHODS</b>Serum samples collected from 196 untreated chronic HBV patients were detected by primer-specific real-time PCR.</p><p><b>RESULTS</b>Among 196 patients, spontaneous YMDD variants were detected in 21 subjects (20 YVDD mutants and 1 YIDD mutant). YMDD variants account for more than 50%, 25% to 50%, 9% to 25% of total virus load in 1, 5 and 15 patients, respectively. Gender, age, HBeAg status, serum viral load, the state of disease and duration of infection were not associated with spontaneous YMDD mutation. Genotype B had higher spontaneous YMDD rate than genotype C (20.00% vs 7.38%, x(2) = 6.28, P < 0.05).</p><p><b>CONCLUSION</b>Spontaneous YMDD variants exist in chronic hepatitis B patients, Genotype B is associated with higher spontaneous YMDD rate.</p>
Full text:
1
Index:
WPRIM
Main subject:
Virology
/
Blood
/
DNA, Viral
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Hepatitis B virus
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Polymerase Chain Reaction
/
Sensitivity and Specificity
/
DNA Primers
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Viral Load
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Hepatitis B, Chronic
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Genetics
Type of study:
Diagnostic_studies
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Hepatology
Year:
2009
Type:
Article