Application of chromosomal microarray analysis for a cohort of Chinese patients with spontaneous miscarriage / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 442-446, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-247661
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between spontaneous miscarriage and chromosomal aberrations identifiable with chromosomal microarray analysis (CMA).</p><p><b>METHODS</b>A total of 440 product-of-conceptions were collected for the CMA testing.</p><p><b>RESULTS</b>Four hundred and seventeen of 440 specimens (94.7%) were successfully detected, among which 209 (50.1%) were chromosomal abnormalities. One hundred and twenty-nine (61.7%) of the 209 specimens were numerical chromosomal abnormalities, 40 specimens (19.1%) were structural anomalies, 38 specimens (18.1%) were mosaicisms, and 2 specimens (1.0%) showed regions of homozygosity.</p><p><b>CONCLUSION</b>CMA analysis of products of-conception specimens can yield a higher diagnostic rate than conventional karyotyping. The identification of the cause of spontaneous miscarriage can facilitate estimation of recurrence risks for future pregnancies.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Abortion, Spontaneous
/
Cohort Studies
/
Chromosome Aberrations
/
Microarray Analysis
/
Genetics
/
Karyotyping
/
Methods
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2016
Type:
Article
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