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Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases
Journal of Korean Medical Science ; : 1943-1948, 2016.
Article in English | WPRIM | ID: wpr-24788
ABSTRACT
Since liver function is changed by chronic liver diseases, chronic liver disease can lead to different hemorheological alterations during the course of the progression. This study aims to compare alterations in whole blood viscosity in patients with chronic liver disease, focusing on the gender effect. Chronic liver diseases were classified into three categories by patient’s history, serologic markers, and radiologic

findings:

nonalcoholic fatty liver disease (NAFLD) (n = 63), chronic viral hepatitis B and C (n = 50), and liver cirrhosis (LC) (n = 35). Whole blood viscosity was measured by automated scanning capillary tube viscometer, while liver stiffness was measured by transient elastography using FibroScan®. Both systolic and diastolic whole blood viscosities were significantly lower in patients with LC than NAFLD and chronic viral hepatitis (P < 0.001) in male patients, but not in female patients. In correlation analysis, there were inverse relationships between both systolic and diastolic whole blood viscosity and liver stiffness (systolic r = −0.25, diastolic r = −0.22). Whole blood viscosity was significantly lower in male patients with LC than NAFLD or chronic viral hepatitis. Our data suggest that whole blood viscosity test can become a useful tool for classifying chronic liver disease and determining the prognosis for different types of chronic liver diseases.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Blood Viscosity / Capillaries / Hemorheology / Elasticity Imaging Techniques / Non-alcoholic Fatty Liver Disease / Hepatitis / Hepatitis B / Liver / Liver Cirrhosis Type of study: Diagnostic study / Prognostic study Limits: Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Blood Viscosity / Capillaries / Hemorheology / Elasticity Imaging Techniques / Non-alcoholic Fatty Liver Disease / Hepatitis / Hepatitis B / Liver / Liver Cirrhosis Type of study: Diagnostic study / Prognostic study Limits: Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2016 Type: Article