The value of negative lymph node count in prediction of prognosis of advanced gastric cancer / 中华外科杂志
Chinese Journal of Surgery
;
(12): 66-70, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-247888
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the value of negative lymph node count (NLNC) in prediction of prognosis of advanced gastric cancer after radical resection.</p><p><b>METHODS</b>The 544 cases of radical gastrectomy patients with complete clinical and follow-up data between January 2011 and July 2007 were collected. Survival was determined by the Kaplan-Merier method and univariate analysis was done by Log-rank test, Multivariate analysis was performed using the Cox proportional hazard regression model.</p><p><b>RESULTS</b>Univariate analysis showed age (χ(2) = 4.449), T stage (χ(2) = 30.482), N stage (χ(2) = 205.452), location of tumor (χ(2) = 16.649), tumor size (χ(2) = 35.117), macroscopic type (χ(2) = 4.750), histological grade (χ(2) = 6.130), NLNC stage (χ(2) = 150.369) and type of gastrectomy (χ(2) = 25.605) were related to survival. Among them, T stage, N stage, tumor size and NLNC stage were independent risk factors for survival (P < 0.05). The prognostic factors of patients were performed subgroup analysis, NLNC > 15 group can prolong the survival than NLNC ≤ 15 group in the T2 stage (HR = 0.315), T4 stage (HR = 0.401), the same classification of location of tumor (HR = 0.286-0.493), tumor size (HR = 0.336, 0.465), macroscopic type (HR = 0.306, 0.418), histological grade (HR = 0.411, 0.365) and type of gastrectomy (HR = 0.444, 0.358 and 0.356, all P < 0.05). More NLNC can prolong Disease-Free Survival for patient of early recurrence (χ(2) = 8.648, P = 0.003).</p><p><b>CONCLUSIONS</b>Sufficient negative lymph node count can prolong the survival and decrease the risk of early recurrence.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Stomach Neoplasms
/
General Surgery
/
Proportional Hazards Models
/
Multivariate Analysis
/
Mortality
/
Lymph Node Excision
/
Lymphatic Metastasis
/
Neoplasm Recurrence, Local
Type of study:
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2013
Type:
Article
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