Effect of perioperative glucose-insulin-potassium infusions on the prognosis in patients undergoing coronary artery bypass grafting: a meta-analysis / 中华外科杂志
Chinese Journal of Surgery
;
(12): 1021-1026, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-247918
ABSTRACT
<p><b>OBJECTIVE</b>To assess the effect of perioperative glucose-insulin-potassium (GIK) infusions on the prognosis in patients undergoing coronary artery bypass grafting.</p><p><b>METHODS</b>Electronic databases including Cochrane library (Issue 3, 2011), Pubmed, EMbase, Highwire, CBM and CNKI were searched. A meta-analysis of all randomized controlled trials (RCTs) comparing GIK with control in coronary artery bypass grafting was performed. Study selection and meta-analysis were conducted which according to the Cochrane Handbook for systematic reviews. Date were extracted from these trials by 3 reviewers independently and analyzed by RevMan5.0 software.</p><p><b>RESULTS</b>A total of 9 RCTs including 1029 patients were assessed in this study. GIK infusion was associated with significantly fewer perioperative myocardial infarctions (RR = 0.59, 95%CI 0.38 - 0.91, P = 0.02), less inotropic support requirement (RR = 0.44, 95%CI 0.35 - 0.56, P < 0.01), and increase the incidence of postoperative atrial fibrillation (RR = 1.23, 95%CI 1.05 - 1.43, P = 0.009).</p><p><b>CONCLUSIONS</b>GIK significantly reduces myocardial injury and improves cardiac function in patients undergoing coronary artery bypass grafting, but also increases the incidence of postoperative atrial fibrillation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Period
/
Potassium
/
Prognosis
/
Randomized Controlled Trials as Topic
/
Coronary Artery Bypass
/
Glucose
/
Insulin
/
Myocardial Infarction
Type of study:
Controlled clinical trial
/
Prognostic study
/
Systematic reviews
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2012
Type:
Article
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