A comparison of three methods in establishing transplanted model of VX2 tongue carcinoma in rabbits / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 326-329, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-248239
ABSTRACT
<p><b>OBJECTIVE</b>To establish transplanted models of VX2 tongue carcinoma in rabbits by three methods and compare these models.</p><p><b>METHODS</b>After establishment of VX2 tumor-bearing rabbits, 72 New-Zealand white rabbits were randomly divided into 3 groups. Intact tumour tissue, modified tumour cell suspension, tumour cell suspension were respectively injected into the middle-third lateral border of the tongues of rabbits in 3 groups to induce transplanted VX2 tongue carcinoma. The histological features, the tumour-take rates and the metastasis rates of the 3 models were observed.</p><p><b>RESULTS</b>The tumour-take rate of 3 models were 83.3%, 91.7% and 33.3% respectively; the lymph node metastasis rates were 71.4%, 100.0% and 37.5% respectively; the lung metastasis rates were 35.7%, 81.3% and 0 respectively. The histological features of the transplanted VX2 tongue carcinoma of 3 models were all consistent with those of moderately differentiated carcinoma.</p><p><b>CONCLUSION</b>The biological properties of the transplanted VX2 tongue carcinoma of 3 models is much alike to tongue carcinoma in humans. The model established with modified tumor cell suspension is considered to be more suitable for tongue cancer study.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tongue Neoplasms
/
Carcinoma
/
Disease Models, Animal
/
Lymphatic Metastasis
/
Neoplasm Transplantation
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2009
Type:
Article
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