Clinicopathologic features and prognosis of 51 patients with α-fetoprotein-producing gastric cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 231-234, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-248376
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the clinicopathologic features and prognosis of α-fetoprotein (AFP)-producing gastric cancers (AFPGC).</p><p><b>METHODS</b>Fifty-one serum AFP-positive patients with positive immunohistochemical staining of AFP in the primary lesions (study group) and sixty-five gastric cancer cases with normal AFP level (control group) treated in our department from January 2005 to December 2007 were included in this study. Their clinicopathologic features and follow-up data were statistically analyzed.</p><p><b>RESULTS</b>Compared with the control group, the study group had a higher incidence of poorly differentiated adenocarcinoma (P=0.021) and liver metastasis (P=0.001) than that in the control group.The TNM stages in the study group were significantly higher than those in the control group (P=0.001). The 1-, 2-, and 5-year survival rates of the study group were 62.7%, 27.5% and 4.7%, respectively, and the median survival was 16 months, significantly lower than the 84.6%, 55.4%, 16.5%, and 30 months of the control group (P<0.001 for all). The serum AFP levels in the study group ranged from 58.63 µg/L to 12 100.00 µg/L, and could be classified into two groups27 cases <500 µg/L, and 24 cases ≥500 µg/L. There was no significant difference of the immunohistochemical staining results between the two subgroups (P=0.912).</p><p><b>CONCLUSIONS</b>AFPGC is a special type of gastric cancer with high degree of malignancy and poor prognosis. Monitoring of serum AFP level can earlier detect the progression of disease and give corresponding treatment.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Stomach Neoplasms
/
Adenocarcinoma
/
Alpha-Fetoproteins
/
Incidence
/
Survival Rate
/
Diagnosis
/
Liver Neoplasms
/
Metabolism
Type of study:
Diagnostic study
/
Incidence study
/
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2015
Type:
Article
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