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Efficacy and safety of rituximab combined with CHOP or combined with dose fractionated CHOP in the treatment of primary gastric diffuse large B cell lymphoma / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 939-943, 2014.
Article in Chinese | WPRIM | ID: wpr-248422
ABSTRACT
<p><b>OBJECTIVE</b>The aim of this study was to compare the safety and efficacy profiles of R-CHOP and R-fCHOP regimes in the treatment of primary gastric diffuse large B cell lymphoma (PG-DLBCL).</p><p><b>METHODS</b>Data of PG-DLBCL patients admitted in our hospital from March 2010 to March 2014 were collected retrospectively. Differences in gastrointestinal bleeding and perforation between the R-CHOP group and R-fCHOP group were compared. The influence of the gastrointestinal complication on subsequent treatment was also analyzed. Treatment outcome of the two groups was also compared.</p><p><b>RESULTS</b>A total of 50 patients were included in this retrospective study. Forty of them were in the R-CHOP group, another ten were in the R-fCHOP group. Patients in the R-fCHOP group had a higher rate of Lugano late stage disease, and a relatively high rate of a deeper/larger ulcer. Fence occult blood test (FOBT) was positive in one (10.0%) patient in the R-fCHOP group, and 11 (31.4%) patients in the R-CHOP group, among them one had hematemesis and had to give up the subsequent chemotherapy. No perforation was observed in both groups. The response rate (RR) was 92.5% in the R-CHOP group and 90.0% in the R-fCHOP group (P > 0.05). The PFS was also comparable between the two groups (P > 0.05).</p><p><b>CONCLUSIONS</b>R-fCHOP regimen has a good safety profile in patients with Lugano late stage and deep/large ulcers, who are of high risk of gastrointestinal bleeding or perforation, and also has a comparable efficacy profile when compared with the R-CHOP regimen in short-term follow-up.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Vincristine / Lymphoma, Non-Hodgkin / Prednisone / Antineoplastic Combined Chemotherapy Protocols / Doxorubicin / Retrospective Studies / Lymphoma, Large B-Cell, Diffuse / Treatment Outcome / Cyclophosphamide Type of study: Observational study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Vincristine / Lymphoma, Non-Hodgkin / Prednisone / Antineoplastic Combined Chemotherapy Protocols / Doxorubicin / Retrospective Studies / Lymphoma, Large B-Cell, Diffuse / Treatment Outcome / Cyclophosphamide Type of study: Observational study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2014 Type: Article