High-dose Sulbactam Treatment for Ventilator-Associated Pneumonia Caused by Carbapenem-Resistant Acinetobacter Baumannii / 대한중환자의학회지
Korean Journal of Critical Care Medicine
;
: 308-316, 2016.
Article
in English
| WPRIM
| ID: wpr-24846
ABSTRACT
BACKGROUND:
Several antibiotics can be used to treat ventilator-associated pneumonia caused by carbapenem-resistant A. baumannii (CRAB-VAP) including high-dose sulbactam. However, the effectiveness of high-dose sulbactam therapy is not well known. We report our experience with high-dose sulbactam for treatment of CRAB-VAP.METHODS:
Medical records of patients with CRAB-VAP who were given high-dose sulbactam between May 2013 and June 2015 were reviewed.RESULTS:
Fifty-eight patients with CRAB-VAP were treated with high-dose sulbactam. The mean age was 72.0 ± 15.2 years, and the acute physiology and chronic health evaluation II (APACHE II) score was 15.1 ± 5.10 at the time of CRAB-VAP diagnosis. Early clinical improvement was observed in 65.5% of patients, and 30-day mortality was 29.3%. Early clinical failure (odds ratio [OR] 8.720, confidence interval [CI] 1.346-56.484; p = 0.023) and APACHE II score ≥ 14 at CRAB-VAP diagnosis (OR 10.934, CI 1.047-114.148; p = 0.046) were associated with 30-day mortality.CONCLUSIONS:
High-dose sulbactam therapy may be effective for the treatment of CRAB-VAP. However, early clinical failure was observed in 35% of patients and was associated with poor outcome.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Acinetobacter
/
Sulbactam
/
Medical Records
/
Mortality
/
APACHE
/
Acinetobacter baumannii
/
Diagnosis
/
Pneumonia, Ventilator-Associated
/
Anti-Bacterial Agents
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Critical Care Medicine
Year:
2016
Type:
Article
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