Study on the association of lecithin cholesterol acyltransferase gene polymorphisms with the lipid metabolism in coronary atherosclerotic heart disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 135-137, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-248477
ABSTRACT
<p><b>OBJECTIVE</b>To examine the distribution of 3 polymorphisms of lecithin cholesterol acyltransferase gene in Chinese population and the association of these polymorphisms with lipid metabolism in patients with atherosclerotic heart disease (CHD).</p><p><b>METHODS</b>Genotypes and frequencies of 3 sites were examined by PCR-restriction fragment length polymorphism technique in 209 unrelated normal control individuals and 203 CHD patients.</p><p><b>RESULTS</b>The observed allele frequencies conform well to Hardy-Weinberg equilibrium. The frequency of 608T allele was significantly higher in controls than that in patients (P=0.034). Compared with the CHD patients without 608T, the CHD patients with 608T exhibited a significant increase in plasma HDL-C concentration (P=0.015). 911T/C and 1188C/T polymorphisms were not found in either group.</p><p><b>CONCLUSION</b>608T polymorphism of LCAT gene was associated with higher plasma HDL-C level in CHD patients, while 911T/C and 1188C/T polymorphisms maybe very rare in Chinese population.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Triglycerides
/
Blood
/
Coronary Artery Disease
/
Polymorphism, Restriction Fragment Length
/
DNA
/
Cholesterol, VLDL
/
DNA Restriction Enzymes
/
China
/
Cholesterol
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2003
Type:
Article
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