Mapping studies of type 2 diabetes mellitus gene in one family / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To disclose the molecular genetic mechanism of type 2 diabetes mellitus and to determine chromosomal location of type 2 diabetes mellitus gene.</p><p><b>METHODS</b>Genome-wide screening and genotyping were conducted in a family of type 2 diabetes mellitus, and linkage analysis by LINKAGE and GENEHUNTER package was used to determine the potential chromosomal location of the family of type 2 diabetes mellitus gene.</p><p><b>RESULTS</b>Evidence of linkage was found at the long arm of chromosome 2. The maximum Lod score is 1.80 and non-parameter Lod score is 5.06.</p><p><b>CONCLUSION</b>The type 2 diabetes mellitus gene of the family is located at 2q.</p>