Linkage analysis of susceptibility genes for familial schizophrenia on chromosome 1 in Chinese population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 491-494, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-248521
ABSTRACT
<p><b>OBJECTIVE</b>To explore the molecular genetic relationship between chromosome 1 and susceptibility genes for familial schizophrenia in Chinese population.</p><p><b>METHODS</b>A genome scanning was conducted in 32 multiplex pedigrees from Chinese population by using 29 microsatellite markers on chromosome 1.</p><p><b>RESULTS</b>Multipoint parametric analysis detected a maximum heterogenicity Lod of 1.70 at 262.52 cM under a recessive model; multipoint non-parametric analysis detected a maximum non-parameter linkage (NPL) of 1.71 (P=0.046) at 262.52 cM, then 1.37 (P=0.086) at 149.70 cM, corresponding to marker D1S206 and D1S425 respectively.</p><p><b>CONCLUSION</b>These results give further supports to the presence of susceptibility genes on chromosome 1q for familial schizophrenia.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pedigree
/
Schizophrenia
/
Chromosomes, Human, Pair 1
/
China
/
Family Health
/
Chromosome Mapping
/
Microsatellite Repeats
/
Genetic Predisposition to Disease
/
Genetics
/
Genetic Linkage
Type of study:
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2002
Type:
Article
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