Meta-analysis on relationship between single nucleotide polymorphism of rs2231142 in ABCG2 gene and gout in East Asian population / 中华流行病学杂志

ABSTRACT

Objective To systematically evaluate the association between single nucleotide polymorphism of rs2231142 genetic susceptibility and gout in East Asian population.Methods The literature retrieval was conducted by using English databases (Medline, EMbase), Chinese databases (CNKI, Vip, Wanfang, SinaMed) and others to collect the published papers on the association between single nucleotide polymorphism of rs2231142 genetic susceptibility and gout by the end of December 2014.Meta-analysis was performed with software Stata 12.0.Results Nine studies were included.There were significant associations between increased risk of gout and single nucleotide polymorphism of rs2231142, the combined OR was 2.04 (95％ CI: 1.82-2.28)for A allele and C allele, 1.97 (95％ CI: 1.57-2.48) for CA and CC, 3.71 (95％ CI: 3.07-4.47) for AA and CC.Sex and region specific subgroup analysis showed less heterogeneity.Conclusion There is significant association between gout and single nucleotide polymorphism of rs2231142 in East Asian population,and A allele is a high risk gene for gout.