Genetic risk score: principle, methods and application / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 1062-1064, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-248710
ABSTRACT
Genetic risk score (GRS) is used for evaluating the effects of genetic susceptible factors in risk prediction models.Five methods are commonly used for GRSi.e.simple count genetic risk score (SC-GRS),odds ratio weighted genetic risk score (OR-GRS),direct logistic regression genetic risk score (DL-GRS),polygenic genetic risk score (PG-GRS) and explained variance weighted genetic risk score (EV-GRS).This paper summarizes the models,application conditions,advantages and limitations of the five methods.The complexity of prediction models increased along with the inclusion of more susceptible SNPs,some method have been developed to solve the problems,but the effects of new methods needs further evaluation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS