Comparison of bicyclol therapy for patients with genotype B and C of hepatitis B virus / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 366-368, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-248751
ABSTRACT
<p><b>OBJECTIVE</b>To compare the efficacy of bicyclol tablets on patients infected with hepatitis B virus between genotype B and C.</p><p><b>METHODS</b>70 patients with chronic viral hepatitis B were selected. The patients divide into two groups HBV genotypes B (26 cases) and HBV genotypes C (other 44 cases). All patients received bicyclol tablets orally 150 mg daily (50mg, tid, po) for 24 weeks. The efficacy were observed after 12 weeks and 24 weeks.</p><p><b>RESULTS</b>After treatment for 24 weeks, the serum aminotransferase were decreased obviously, and HBV DNA levels turn to be negative with 19.2 percent (genotype B group) and 15.9 percent (genotype C group), respectively. The difference was not statistically significant between HBV genotype B and C.</p><p><b>CONCLUSION</b>Bicyclol not only has hepatoprotective activity but also inhibited virus replication in patients infected with HBV. The difference of the response to bicyclol therapy between HBV genotypes B and C was not statistically significant.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Biphenyl Compounds
/
Hepatitis B virus
/
Classification
/
Hepatitis B, Chronic
/
Therapeutic Uses
/
Drug Therapy
/
Genotype
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2007
Type:
Article
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