Factors related to the outcome of patients with chronic severe hepatitis B and effectiveness of antivirus therapy / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 120-122, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-248829
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the factors related to the outcome of patients with chronic severe hepatitis B and effectiveness of antivirus therapy.</p><p><b>METHODS</b>The effects of the factors including age, prothrombin activity (PTA), serum HBeAg, Anti-HBe, HBV-DNA load, with or without complication, antivirus therapy and so on, on outcome of 330 patients with chronic severe hepatitis B were analyzed in this retrospective study.</p><p><b>RESULTS</b>The mortality of patients with chronic severe hepatitis B was significantly higher among patients at higher age, with lower PTA, and with more complications. The mortality of patients with HBV-DNA more than 1x10(5) copies/ml (52.3 percent) was higher than that of patients whose HBV-DNA was less than 1x10(5) copies/ml (32.9 percent). There was no correlation between serum HBeAg or anti-HBe and the mortality. The mortality of patients with HBV-DNA higher than 1x10(5) copies/ml (30.38 percent) who were treated with lamivudine in 2005 was lower than that of patients whose HBV-DNA was less than 1x10(5) copies/ml (54.64 percent) who were not treated with any antiviral therapy in 2001.</p><p><b>CONCLUSION</b>The higher serum virus load is the key factors of the mortality in addition to the other factors such as older age, lower PTA, more complication in the patients with chronic severe hepatitis B. The usage of antivirus therapy may be associated with lower mortality.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Blood
/
Prothrombin
/
Hepatitis B virus
/
Mortality
/
Age Factors
/
Treatment Outcome
/
Lamivudine
/
Viral Load
/
Hepatitis B, Chronic
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2007
Type:
Article
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