Preparation and characterization of genipin-crosslinked silk fibroin/chitosan controlled-release microspheres / 南方医科大学学报
Journal of Southern Medical University
;
(12): 875-879, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-249341
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the property of genipin-crosslinked silk fibroin(SF)/chitosan(CS) microspheres for slow releasing of bovine serum albumin (BSA).</p><p><b>METHODS</b>BSA-loaded genipin-crosslinked SF/CS microspheres were prepared by emulsion cross-linking technique. The micropheres were observed for surface morphology and size distribution under scanning electron microscope (SEM), and X-ray diffractometry (XRD) and fourier transform infrared spectroscopy (FTIR) were used to analyze their structural characteristics. BCA method was used for determining the drug entrapment, loading rate and cumulative drug release in 21 days.</p><p><b>RESULT</b>The microspheres were spherical and showed a smooth surface with an average diameter of 7.84∓0.97 µm. The drug entrapment efficiency of the microspheres was (50.16∓4.32)% with a drug loading ratio of (1.25∓0.11)% and a cumulative release of the total drug of (75.2∓2.53)% in 21 days.</p><p><b>CONCLUSION</b>Genipin-crosslinked SF/CS microspheres have a high drug entrapment efficiency and possess good capacity of sustained drug release.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
X-Ray Diffraction
/
X-Rays
/
Microscopy, Electron, Scanning
/
Chemistry
/
Spectroscopy, Fourier Transform Infrared
/
Delayed-Action Preparations
/
Iridoids
/
Chitosan
/
Emulsions
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS