Role of Sam68 in proliferation, invasion and migration of colorectal cancer cells in vitro / 南方医科大学学报
Journal of Southern Medical University
;
(12): 546-551, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-249411
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of Sam68 (Src-associated substrate during mitosis 68 kD) in the occurrence and development of colorectal cancer.</p><p><b>METHODS</b>Colorectal cancer cell lines with stable Sam68 over-expressing and low Sam68 expression were established to test the effect of Sam68 in the proliferation, invasion, and migration of the cancer cells using colony formation, MTT and Transwell assays.</p><p><b>RESULTS</b>SW480 and Ls174t colorectal cell lines over-expressing Sam68 showed significantly enhanced cell proliferation, invasion and migration (P<0.05). Conversely, the low Sam68 expression in SW620 and HCT116 colorectal cell lines significantly suppressed the cell proliferation, invasion and migration (P<0.05).</p><p><b>CONCLUSION</b>The expression of Sam68 can promote the proliferation, invasion and migration of colorectal cancer cells lines in vitro.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Colorectal Neoplasms
/
Cell Movement
/
RNA-Binding Proteins
/
Cell Cycle Proteins
/
Cell Line, Tumor
/
Adaptor Proteins, Signal Transducing
/
Cell Proliferation
/
DNA-Binding Proteins
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
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