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Is KPNB3 locus associated with schizophrenia? / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 52-55, 2007.
Article in English | WPRIM | ID: wpr-249888
ABSTRACT
<p><b>OBJECTIVE</b>To reconfirm the association of KPNB3 with schizophrenia in Chinese population.</p><p><b>METHODS</b>Two single nucleotide polymorphisms (SNPs), rs2588014 and rs626716 at the KPNB3 locus, were genotyped in 304 Chinese Han family trios consisting of fathers, mothers, and affected offsprings with schizophrenia. These 2 SNPs were detected by PCR-based restriction fragment length polymorphism (RFLP) analysis. The Hardy-Weinberg equilibrium for genotypic distributions was estimated by the goodness-of-fit test. The UNPHASED program was used to perform transmission disequilibrium test (TDT), haplotype analysis, and pair-wise measure of linkage disequilibrium (LD) between these 2 SNPs.</p><p><b>RESULTS</b>The genotypic distributions of both rs2588014 and rs626716 were in the Hardy-Weinberg equilibrium (P > 0.05). The TDT revealed allelic association with rs626716 (chi2 = 9.31, P = 0.0023) but not with rs2588014 (chi2 = 3.44, P = 0.064). The global P-value was 0.0099 for 100 permutations. The haplotype analysis also showed a disease association (chi2 = 25.97, df = 3, P = 0.0000097).</p><p><b>CONCLUSION</b>The present study provides further evidence in support of the KPNB3 association with schizophrenia in Chinese population.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Schizophrenia / China / Epidemiology / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Beta Karyopherins / Genetics / Genotype Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Biomedical and Environmental Sciences Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Schizophrenia / China / Epidemiology / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Beta Karyopherins / Genetics / Genotype Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Biomedical and Environmental Sciences Year: 2007 Type: Article