Action of Schwann cells implanted in cerebral hemorrhage lesion / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 47-51, 2007.
Article
in English
| WPRIM
| ID: wpr-249889
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether there is neogenesis of myelin sheath and neuron after transplantation of Schwann cells into cerebral hemorrhage lesion.</p><p><b>METHODS</b>Schwann cells were expanded, labeled with BrdU in vitro and transplanted into rat cerebral hemorrhage with blood extracted from femoral artery and then injected into the basal nuclei. Double immunohistochemistry staining and electron microscopy were used to detect the expression of BrdU/MBP and BrdU/GAP-43 and remyelination.</p><p><b>RESULTS</b>BrdU/MBP double positive cells could be seen at 1 week up to 16 weeks after transplantation of Schwann cells. Thin remyelination was observed under electron microscope. GAP-43 positive cells appeared after 12 weeks and were found more in Hippocamp.</p><p><b>CONCLUSIONS</b>Grafted Schwann cells participate in remyelination and promoter nerve restore in rat cerebral hemorrhage.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schwann Cells
/
Sciatic Nerve
/
Therapeutics
/
Transplantation
/
Cerebral Hemorrhage
/
Embryology
/
Rats, Wistar
/
GAP-43 Protein
/
Cell Biology
/
Metabolism
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2007
Type:
Article
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