The preliminary report of occult HBV infection in Vietnamese
Journal of Medical Research
;
: 28-32, 2007.
Article
in Vietnamese
| WPRIM
| ID: wpr-250
ABSTRACT
Background:
Vietnam is located in the endemic region of hepatitis B virus (HBV) infection, but no data of occult HBV infection was reported at present.Objectives:
To investigate the prevalence of occult HBV infection in different ethnics of people and generations. Subjects andmethod:
80 voluteers with HbsAg negative from five different ethnics Kinh, Tay, Mong, Giay and Dao in a Chino \ufffd?Vietnamses border province (Lao Cai) were enrolled in the study. After HBV-DNA was extracted, nested PCR of S gene and of Core-promoter/Pre-core region were used to detect HBV-DNA. Specifying nucleotide sequence was confirmed by direct sequencing.Results:
The prevalence of occult HBV infection in population study was very high 73/80 (91,3%) by nested PCR of Core-promoter/Pre-core, significantly more sensitive than nested PCR of S gene (26,3%) (p<0,0001). The prevalence of occult HBV infection was notdifferent between ethnics of people or between children, adults.Conclusion:
Occult HBV infection in Vietnamese is very common; however, nationwide further studies should be carried out to confirm this preliminary results and evaluate the impact of occult HBV infection in Vietnam.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Hepatitis B virus
/
Hepatitis B Surface Antigens
Language:
Vietnamese
Journal:
Journal of Medical Research
Year:
2007
Type:
Article
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