Correlation of polymorphisms of interleukin-2 gene and HBV DNA copies in patients with chronic hepatitis B / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 889-892, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-250089
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationships of polymorphisms of interleukin-2 (IL-2) gene to the susceptibility of chronic hepatitis B, and to analyze the frequencies of IL-2 gene polymorphisms and the HBV-DNA copies in patients with chronic hepatitis B.</p><p><b>METHODS</b>Two single nucleotide polymorphisms of IL-2 gene promoter -385T/G and +114T/G at exon one were analyzed in 155 patients with chronic hepatitis B and in 170 age- and sex-matched controls from a Chinese population. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) strategy and DNA sequencing were used, and the serum HBV DNA in these patients was determined by real-time PCR.</p><p><b>RESULTS</b>There were no differences in the distributions of IL-2 gene +114T/G polymorphism in the patient group and the controls, but their IL-2 gene -385T/G polymorphisms were significantly different (P less than 0.05). The relative risk of being chronic hepatitis B victims with T allele was 1.490 times of those with G allele (OR=1.490, 95% CI 1.085-2.046). The association between the genotype of IL-2 gene polymorphisms and HBV-DNA copies showed that the frequency of -385G allele carriers in high HBV-DNA copy group was closer than that in low HBV-DNA copy group (chi2=6.051, P=0.014).</p><p><b>CONCLUSIONS</b>IL-2 gene -385T/G polymorphism is associated with chronic hepatitis B and G allele is an important genetic susceptibility gene for chronic hepatitis B. In IL-2 gene -385G allele carriers the risk of increasing HBV-DNA copies may be related to the pathogenesis of chronic hepatitis B.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Polymorphism, Restriction Fragment Length
/
DNA, Viral
/
Case-Control Studies
/
Hepatitis B virus
/
Interleukin-2
/
Hepatitis B, Chronic
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Asian People
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2008
Type:
Article
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