Expression of type I inositol 1,4,5-triphosphate receptor on rat glomerular and afferent arterioles in a model of liver cirrhosis / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 609-611, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-250133
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of type I inositol 1,4,5-triphosphate receptor in rat glomerular and afferent arterioles in a model of liver cirrhosis and study the role of cross-membrane message transduction in the pathogenesis of hepatorenal syndrome.</p><p><b>METHODS</b>In a rat model of carbontetrachloride liver cirrhosis, the expression of type I inositol 1,4,5-triphosphate receptor (IP3R) on glomerular and afferent arterioles was measured by immunohistochemical method.</p><p><b>RESULTS</b>In the experimental group, 30 rats were used to make a model of liver cirrhosis. 11 rats survived during the experiment. The expression of type I IP3R on glomerular and afferent arterioles was 4.97+/-1.34 and 4.09+/-1.14 in the liver cirrhosis group, and it was 2.43+/-1.67 and 1.83+/-1.32 in the normal control rats. The differences between these two groups are statistically significant (t = 2.28, P = 0.0458).</p><p><b>CONCLUSION</b>Expression of type I IP3 receptor on rat glomerular and afferent arterioles in a model of liver cirrhosis indicated that the mechanism of cross-membrane message transduction plays a very important role in the pathogenesis of hepatorenal syndrome.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arterioles
/
Renal Artery
/
Carbon Tetrachloride
/
Carbon Tetrachloride Poisoning
/
Calcium Channels
/
Random Allocation
/
Rats, Wistar
/
Receptors, Cytoplasmic and Nuclear
/
Inositol 1,4,5-Trisphosphate Receptors
/
Genetics
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2004
Type:
Article
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