The pegasys using and HCV genotype were the independent predictors of the response to antiviral therapy in chronic hepatitis C / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 485-488, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-250188
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the predictors of IFN therapy in patients with chronic hepatitis C through making the multivariate logistic regression analysis.</p><p><b>METHODS</b>The patients in the opened, randomized and controlled trial were enrolled into two group, pegasys and Roferon-A group, and were given 24 weeks of pegasys (injection of 180 microg a week), and Roferon-A (injection three times of Roferon-A 3 MU a week) therapy, and followed 24 weeks. The HCV RNA content was determined at the time before, end of treatment and at the followed-up. The association of the response to the treatment with the clinical characteristics including age, gender, way of HCV infection, history of IFN treatment, planet count, AST/ALT ratio, HCV RNA level, HCV genotype and treatment drugs was made trough multivariate logistic regression analysis.</p><p><b>RESULTS</b>The PP population containing 197 cases was analyzed. After controlling for age, gender, way of HCV infection, history of IFN treatment, planet count, AST/ALT ratio, HCV RNA level and treatment, the HCV genotype was not predictor of the end of treatment viral response (ETVR) to IFN therapy (OR 0.604, 95% CI 0.271-1.349, P = 0.219), but was the independent predictor of sustained viral response (SVR) (OR 0.408, 95% CI 0.189-0.881, P = 0.023). After controlling for other characteristics, the treatment drug was the predictors of ETVR (OR 0.105, 95% CI 0.052-0.212, P < 0.001) and SVR (OR 0.255, 95% CI 0.123-0.529, P < 0.001).</p><p><b>CONCLUSION</b>The pegasys using and HCV genotype were the independent predictors of the response to antiviral therapy in chronic hepatitis C.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Polyethylene Glycols
/
Virology
/
Blood
/
Recombinant Proteins
/
RNA, Viral
/
Logistic Models
/
Follow-Up Studies
/
Interferon-alpha
/
Hepacivirus
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2004
Type:
Article
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