Anti-platelet aggregation bioassay based quality control for XST capsules / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 4597-4602, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-250447
ABSTRACT
A in vitro platelet aggregation bioassay was developed for the quality control of XST capsules. The in vitro anti-platelet aggregation effect in rats was observed to detect the bioactivity of XST capsules. Panax notoginseng saponins and Xuesaitong lyophilizedpowder for injection were taken as standard control substances to determine the potency. According to the results, XST capsules showeda significant inhibitory effect on thrombin-induced platelet aggregation in a dose-dependent manner. The in vitro anti-platelet activity oflyophilized powder for injection was stabler than that of Panax notoginseng saponins, and so suitable to serve as a standard control substance. The biological potency of XST capsules compared with standard control substance was detected by using parallel line assay. According to the results, the established bioassay method had a good repeatability (RSD 2.92%). The sample test results could pass thereliability test(linear deviation P > 0.05, parallel deviation P > 0.05). This bioassay method could be used as one of the complementary quality control methods for XST capsules.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Saponins
/
Capsules
/
Drugs, Chinese Herbal
/
Platelet Aggregation Inhibitors
/
Chemistry
/
Platelet Aggregation
/
Rats, Sprague-Dawley
/
Panax notoginseng
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2015
Type:
Article
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