The correlation of serum cholinesterase and clinical signs in acute organophosphate poisoning

ABSTRACT

30 acute organophosphate poisoning patients admitted in our department were classified into three groups of severity based on serum cholinesterase level and clinical syndromes of cholinergic crisis. Atropine was given at dose of 2-5mg every 10-15 minutes until the atropinisation reached then the doses of atropine were adjusted to maintain it. Pralidoxime was administered according to severity and its dosages were titrated as serum cholinesterase levels and clinical changes. Data was analyzed by SPSS for Windows. (1) The patients had good outcome with short duration of hospitalization (5.73.8) and low mortality (3.3%). (2) Serum cholinesterase was correlated with number of clinical symptoms (r=-0.613); clinical score (r=-0.580); number clinical syndromes (r=-0.515); total dose of atropine (-.714) severity of poisoning (r=-0.928) and total dose of PAM (r=-0.721). All correlation was significantly at the 0.01 level. (3) Total dose of PAM was correlated with clinical symptoms (r=0.625); clinical score (r=0.596); clinical syndromes (r=0.658); severity of poisoning (0.695); duration of hospitalization (0.889)