Dynamic variation of serum and stool level of interleukin-2, interleukin-6 and interferon-alpha in children with rotavirus enteritis and its relation to clinical manifestations / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 270-273, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-250537
ABSTRACT
<p><b>OBJECTIVE</b>This study was conducted to observe dynamically the serum and stool level of IL-2, IL-6 and IFN-alpha with RV enteritis, and to analyse the relation of them and their relation to clinical manifestations.</p><p><b>METHODS</b>The double-antibody sandwich ELISA technique was applied.</p><p><b>RESULTS</b>The positive rate of RV in 119 enteritis cases was 63.0% and the peak month was November. These cytokines had different peak phases in the course of disease. The earliest cytokine which had peak phase was IFN-alpha, the last ones were serum and stool IL-2. There was a negative relation between stool IL-2 and IL-6 (P<0.01). There were positive relation between IL-2 and IFN-alpha, stool IL-6 and IFN-alpha, serum IL-2 and IL-6, stool IL-2 and the recovery time of the enteritis (P<0.01 or P<0.05). Serum and stool level of IL-2 and IFN-alpha had positive relation to the number of lymphocyte plus mononuclear cells (P<0.01 or P<0.05).</p><p><b>CONCLUSIONS</b>IL-2, IL-6 and IFN-alpha play important roles of immunoregulation in RV enteritis, and have close relation to clinical manifestations.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rotavirus Infections
/
Virology
/
Blood
/
Chemistry
/
Interleukin-6
/
Interferon-gamma
/
Interleukin-2
/
Enteritis
/
Feces
/
Metabolism
Limits:
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2002
Type:
Article
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