The crystalline polymorph control and selection of gabapentin with polymer heteronuclei / 药学学报
Acta Pharmaceutica Sinica
;
(12): 109-113, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-250611
ABSTRACT
The pharmaceutical properties, including the physical and chemical properties, and the bioavailability are greatly influenced by their polymorphism. In this paper the polymer heteronuclei were used to produce the gabapentin polymorphs that were characterized by X-ray powder diffraction, FT-IR and DSC. The results indicated that the polymer heteronuclei are an effective method to control and select the gabapentin polymorphism. One new polymorph of gabapentin was found besides all known gabapentin polymorphs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymers
/
X-Ray Diffraction
/
Calorimetry, Differential Scanning
/
Molecular Structure
/
Chemistry
/
Spectroscopy, Fourier Transform Infrared
/
Crystallization
/
Cyclohexanecarboxylic Acids
/
Gamma-Aminobutyric Acid
/
Amines
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Type:
Article
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