Advances in the study of HIV-1 integrase inhibitors of alpha, gamma-diketo compounds / 药学学报
Acta Pharmaceutica Sinica
;
(12): 215-223, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-250639
ABSTRACT
HIV-1 integrase (IN) is an essential enzyme for retroviral replication. There is no analogue for this enzyme in human cells so that inhibition of IN will not bring strong effect on human body. Thus, HIV-1 IN has become a rational target for therapy of AIDS. This review provides a comprehensive report of alpha, gamma-diketo IN inhibitors discovered in recent years. Compilation of such data will prove to be beneficial in developing QSAR, pharmacophore hypothesis generation and validation, virtual screening and synthesis of compounds with higher activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Molecular Structure
/
Chemistry
/
HIV-1
/
HIV Integrase Inhibitors
/
HIV Integrase
/
Anti-HIV Agents
/
Quantitative Structure-Activity Relationship
/
Keto Acids
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Type:
Article
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