HIV entry inhibitors: progress in development and application / 药学学报
Acta Pharmaceutica Sinica
;
(12): 131-140, 2010.
Article
in English
| WPRIM
| ID: wpr-250660
ABSTRACT
This review discusses recent progress in the development of anti-HIV agents, with emphasis on small molecule HIV-1 entry inhibitors. The entry inhibitors primarily target HIV-1 envelope glycoproteins or the cellular receptors, CD4 and chemokine receptors. Two of the entry inhibitors, enfuvirtide and maraviroc, have been approved by the US FDA for AIDS therapy. The drug resistance associated with some of the entry inhibitors will also be discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptide Fragments
/
Pharmacology
/
Physiology
/
Triazoles
/
Molecular Structure
/
CD4 Antigens
/
HIV Envelope Protein gp41
/
HIV Envelope Protein gp120
/
HIV Infections
/
Chemistry
Limits:
Humans
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Type:
Article
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