Effect of Combined Treatment with Cyclosporine A and Cord Serum for Dry Eye Associated with Graft-Versus-Host-Disease
Journal of the Korean Ophthalmological Society
;
: 587-594, 2013.
Article
in Korean
| WPRIM
| ID: wpr-25077
ABSTRACT
PURPOSE:
To investigate the efficacy of combined treatment with 0.05% cyclosporine A and 20% umbilical cord serum eye drops for severe dry eye associated with graft-versus-host disease (GVHD).METHODS:
Eighteen patients with severe dry eye associated with GVHD were treated with 0.05% cyclosporine A and 20% umbilical cord serum eye drops (group 1, n = 16), 0.05% cyclosporine A eye drops (group 2, n = 10) or artificial tears only (group 3, n = 10). Tear film break up time (BUT), Schirmer test, tear clearance rate (TCR), and keratoepithelio pathy score were measured before and 1, 3 and 6 months after treatment.RESULTS:
In group 1, significant improvement was observed in tear film BUT (from 3.25 +/- 1.18 s to 6.63 +/- 0.96 s, p < 0.01), TCR (from 2.38 +/- 0.72 to 3.13 +/- 0.72, p < 0.01) and keratoepithelio pathy score (from 6.31 +/- 2.15 to 0.88 +/- 0.89, p < 0.01) 6 months after treatment. Compared with group 2 and group 3, group 1 showed significant improvement in BUT (3 and 6 months after treatment) and keratoepitheliopathy score (1, 3 and 6 months after treatment).CONCLUSIONS:
Combined treatment with 0.05% cyclosporine A and 20% umbilical cord serum eye drops is effective for severe dry eye associated with GVHD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ophthalmic Solutions
/
Tears
/
Umbilical Cord
/
Cyclosporine
/
Eye
/
Graft vs Host Disease
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2013
Type:
Article
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