Relationship between interleukin-6 gene-572C/G polymorphism and chronic periodontitis / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 410-413, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-251043
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between interleukin-6 (IL-6) gene -572C/G polymorphism and the risk of chronic periodontitis disease.</p><p><b>METHODS</b>IL-6-572C/G genotype polymorphism was examined in 93 patients with chronic periodontitis and 96 control subjects by PCR restriction fragment length polymorphism (PCR-RFLP) method.</p><p><b>RESULTS</b>IL-6-572GG genotype and G allele were more frequent in chronic periodontitis patients than that in control subjects (P<0.05). -572CC, CG and GG genotype frequency were 52.7 % , 40.9 %, 6.4 % in chronic periodontitis patients and 67.7 %, 31.3%, 1.0 % in control subjects, respectively. -572CG + GG genotype and G allele were more frequent in patients than that in control subjects (P<0.05). Compared with CC genotype,the odds ratio for chronic periodontitis was 1.88 (95% CI 1.04-3.40, P<0.05) for CG + GG genotype.</p><p><b>CONCLUSIONS</b>The frequency of -572CG + GG genotype was higher in patients with chronic periodontitis compared with the control subjects. IL-6-572C/G polymorphism may be a genetic susceptibility factor for chronic periodontitis in Chinese Hans population.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Case-Control Studies
/
Interleukin-6
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Alleles
/
Chronic Periodontitis
/
Gene Frequency
/
Genetics
/
Genotype
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Stomatology
Year:
2008
Type:
Article
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