Study on the active spirostanol saponins of Gualou xiebai baijiutang / 药学学报
Acta Pharmaceutica Sinica
;
(12): 433-437, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-251067
ABSTRACT
<p><b>AIM</b>To study the basis of actions of Gualou xiebai baijiutang.</p><p><b>METHODS</b>Guided by bioactivities, chemical and chromatographic ways were applied to isolate and purify the prescription. The chemical structures were identified by chemical and spectral ways. The activities on cardiovascular system of the pure compounds were measured.</p><p><b>RESULTS</b>Seven steroidal compounds were isolated and identified from the active parts.</p><p><b>CONCLUSION</b>Compounds 5 and 6 showed good anti-platelet aggregation activities induced by ADP and PAF. The IC50 of compound 5 and 6 induced by 2 mumol.L-1 ADP were 0.082 and 0.078 mmol.L-1, and the IC50 induced by 0.5 mumol.L-1 PAF were 0.182 and 0.151 mmol.L-1, respectively.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Saponins
/
Allium
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Chemistry
/
Platelet Aggregation
/
Trichosanthes
/
Ethanol
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Type:
Article
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