Studies on antidiabetic effects of cortex Moutan polysaccharide-2b in type 2 diabetes mellitus rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 255-259, 2003.
Article
in English
| WPRIM
| ID: wpr-251130
ABSTRACT
<p><b>AIM</b>To study the antidiabetic effects of cortex Moutan polysaccharide-2b (CMP-2b) in type 2 diabetes mellitus (T2DM) rats.</p><p><b>METHODS</b>The T2DM model rats were induced by a single intravenous injection of low dose streptozotocin (STZ) and intake of high sucrose-fat diet. CMP-2b was given to T2DM rats daily through gavage for 4-5 weeks. The body weight, water and food intake, fasting blood glucose (FBG), glucose tolerance, plasma lipids, serum insulin, and insulin receptor (Ins R) were determined.</p><p><b>RESULTS</b>Oral administration of CMP-2b significantly decreased water and food intake, FBG, total cholesterol (Tch), and triglyceride (TG), improved the impaired glucose tolerance (IGT), and remarkably raised the number of low affinity InsR and insulin sensitivity index (ISI) in T2DM rats.</p><p><b>CONCLUSION</b>CMP-2b may be useful for treating T2DM and its complications.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Polysaccharides
/
Blood
/
Blood Glucose
/
Body Weight
/
Receptor, Insulin
/
Drugs, Chinese Herbal
/
Chemistry
/
Rats, Wistar
/
Glucose Intolerance
Limits:
Animals
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Type:
Article
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