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Mathematic modeling and experimental validation of macrostate quality expression for multicomponent in Chinese materia medica / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 3096-3103, 2011.
Article in Chinese | WPRIM | ID: wpr-251188
ABSTRACT
<p><b>OBJECTIVE</b>To establish the unitive multicomponent quality system bridged macrostate mathematic model parameters of material quality and microstate component concentration for Chinese materia medica (CMM).</p><p><b>METHOD</b>According to law of biologic laws of thermodynamics, the state functions of macrostate qulity of the CMM were established. The validation test was carried out as modeling drug as alcohol extract of Radix Rhozome (AERR), their enthalpy of combustion was determined, and entropy and the capability of information by chromatographic fingerprint were assayed, and then the biologic apparent macrostate parameters were calculated.</p><p><b>RESULT</b>The biologic macrostate mathematic models, for the CMM quality controll, were established as parameters as the apparent equilibrium constant, biologic enthalpy, Gibbs free energy and biologic entropy etc. The total molarity for the 10 batchs of AERR were 0.153 4 mmol x g(-1) with 28.26% of RSD, with the average of apparent equilibrium constants, biologic enthalpy, Gibbs free energy and biologic entropy were 0.039 65, 8 005 J x mol(-1), -2.408 x 10(7) J x mol(-1) and - 8.078 x 10(4) J x K(-1) with RSD as 6.020%, 1.860%, 42.32% and 42.31%, respectively.</p><p><b>CONCLUSION</b>The macrostate quality models for CMM can represent their intrinsic quality for multicomponent dynamic system such as the CMM, to manifest out as if the forest away from or tree near from to see it.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality Control / Thermodynamics / Drugs, Chinese Herbal / Materia Medica / Models, Theoretical Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality Control / Thermodynamics / Drugs, Chinese Herbal / Materia Medica / Models, Theoretical Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2011 Type: Article