Study on balance group in steady-state extraction process of Chinese medicine and experimental verification to Houttuynia cordata / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To establish and experimental verification the mathematical model of the balance groups that is the steady-state of traditional Chinese medicine in extraction.</p><p><b>METHOD</b>Using the entropy and genetic principles of statistics, and taking the coefficient of variation of GC fingerprint which is the naphtha of the Houttuynia cordata between strains in the same GAP place as a pivot to establish and verify the mathematical model was established of the balance groups that is the steady-state of traditional Chinese medicine in extraction.</p><p><b>RESULT</b>A mathematical model that is suitable for the balance groups of the steady-state of traditional Chinese medicine and preparation in extraction, and the balance groups which is 29 683 strains (approximately 118.7 kg) were gained with the same origin of H. cordata as the model drug.</p><p><b>CONCLUSION</b>Under the GAP of quality control model, controlling the stability of the quality through further using the Hardy-Weinberg balance groups of the H. cordata between strains, the new theory and experiment foundation is established for the steady-state of traditional Chinese medicine in extraction and quality control.</p>