Juvenile xanthogranuloma: 3 cases report and literature review / 中华血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To report the clinical characteristics and treatment of 3 patients with juvenile xanthogranuloma (JXG).</p><p><b>METHODS</b>A retrospective review of the medical records of 3 patients with JXG.</p><p><b>RESULTS</b>JXG was characterized by solitary or multiple yellowish cutaneous nodules, or eye involvement . It could also affect pituitary. JXG was easily misdiagnosed as Langerhans cell histiocytosis (LCH). Treatment for JXG was surgical excision of a solitary skin lesion and some cases might be, spontaneous regression. In cases with multisystem involvement, chemotherapy regimens used to treat LCH may be effective.</p><p><b>CONCLUSIONS</b>JXG is one of the more common non-Langerhans histiocytic proliferations and is frequently seen in infants and children. LCH-like chemotherapy is effective for patients with symptomatic multisystem JXG.</p>