Progress on genetic basis of primary aldosteronism / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 612-618, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-251655
ABSTRACT
It has been proven that familial aldosteronism type I is related to 11-beta hydroxylase (CYP11B1)/aldosterone synthase (CYP11B2) chimeric genes. In recent years, accumulated evidences indicate that the genetic basis of primary aldosteronism may involve chromosome 7p22 candidate genes, polymorphisms of CYP11B1 and CYP11B2 genes, mutations of ion channel- related KCNJ5, ATP1A1, CACNA1D genes. The article reviews the progress on genetic basis of primary aldosteronism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Steroid 11-beta-Hydroxylase
/
Cytochrome P-450 CYP11B2
/
Genetics
/
Hyperaldosteronism
/
Mutation
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2014
Type:
Article
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