Targeting angiogenesis and vascular remodeling as a novel therapeutic approach to liver fibrosis / 药学学报
Acta Pharmaceutica Sinica
;
(12): 535-540, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-251745
ABSTRACT
Development of liver fibrosis is closely associated with angiogenesis and abnormal vascular remodeling. Recent studies have highlighted the importance of angiogenesis and vascular remodeling in fibrogenesis, the results that inhibition of angiogenesis is effective in suppression of liver fibrosis demonstrate that therapies with several molecular targets against angiogenesis, inflammation and fibrosis might be beneficial for the treatment of cirrhosis. However, there is some evidence that inhibition of angiogenesis can even worsen fibrosis. This article outlines recent advances regarding the interplay between inflammation, angiogenesis and fibrogenesis in terms of cellular and molecular mechanisms, and suggests a requirement of greater understanding to intervene in these key processes, such as liver sinusoidal endothelial cell fenestration and impact distinct chemokine actions driving monocyte migration and differentiation, for therapeutic benefit in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Vascular Remodeling
/
Inflammation
/
Liver Cirrhosis
/
Neovascularization, Pathologic
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Type:
Article
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