Diversity-oriented synthesis and its application in drug discovery / 药学学报
Acta Pharmaceutica Sinica
;
(12): 419-433, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-251762
ABSTRACT
Diversity-oriented synthesis (DOS) aims to efficiently generate collections of small molecules with diverse appendages, functional groups, stereochemistry and skeletons, thus yielding diverse biological activities capable of modulating a wide variety of biological processes. In this review, we discussed the common strategies employed in DOS with specific examples from recent literature, including reagent-based approach, substrate-based approach, build-couple-pair strategy and privileged substructure-based DOS. The application of some DOS libraries in drug discovery is also presented.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drug Design
/
Small Molecule Libraries
/
Drug Discovery
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Type:
Article
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