The TGF-β signaling pathway induced EMT in breast cancer / 药学学报
Acta Pharmaceutica Sinica
;
(12): 385-392, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-251767
ABSTRACT
Epithelial-mesenchymal transition (EMT) refers to tne transition during which epithelial cells undergo the loss of apical-basal polarity, acquisition of migration capability and transformation into mesenchymal cells. EMT induces breast cancer in situ to developing into metastasis and associates with the drug resistence. The multiple elements including signal pathways, transcriptional factors and downstream genes orchestrate the transition. Among them, the transforming growth factor β (TGF-β) signaling pathway plays a key role in the regulation of EMT in breast cancer. And this paper reviews the development of TGF-β signaling pathway induced EMT in breast cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Transcription Factors
/
Breast Neoplasms
/
Signal Transduction
/
Transforming Growth Factor beta
/
Epithelial Cells
/
Epithelial-Mesenchymal Transition
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Type:
Article
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