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Research progress of p70 ribosomal protein S6 kinase inhibitors / 药学学报
Acta Pharmaceutica Sinica ; (12): 261-271, 2015.
Article in Chinese | WPRIM | ID: wpr-251785
ABSTRACT
p70 ribosomal protein S6 kinase (p70S6K), an important member of AGC family, is a kind of multifunctional Ser/Thr kinases, which plays an important role in mTOR signaling cascade. The p70 ribosomal protein S6 kinase is closely associated with diverse cellular processes such as protein synthesis, mRNA processing, glucose homeostasis, cell growth and apoptosis. Recent studies have highlighted the important role of S6K in cancer, which arose interests of scientific researchers for the design and discovery of anti-cancer agents. Herein, the mechanisms of S6K and available inhibitors are reviewed.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Signal Transduction / Chemistry / Ribosomal Protein S6 Kinases, 70-kDa / Protein Kinase Inhibitors / TOR Serine-Threonine Kinases / Metabolism / Antineoplastic Agents Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Signal Transduction / Chemistry / Ribosomal Protein S6 Kinases, 70-kDa / Protein Kinase Inhibitors / TOR Serine-Threonine Kinases / Metabolism / Antineoplastic Agents Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2015 Type: Article