"PEG dilemma" for liposomes and its solving approaches / 药学学报
Acta Pharmaceutica Sinica
;
(12): 252-260, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-251786
ABSTRACT
Polyethylene glycol (PEG) is extensively used to increasing the in vivo and in vitro stability of liposomes. However, PEGylated liposomes also produce some negative effects with further research, such as low cellular uptake, poor "endosomal escape" of pH sensitive liposome (PSL) and accelerated blood clearance (ABC) phenomenon, and this situation is referred as the "PEG dilemma". "PEG dilemma" posed severe challenges for the targeted delivery of PEGylated liposomes-loaded anticancer drugs, effective intracellular release of PEGylated PSL-encapsulated gene and protein drugs, and repeated administration of PEGylated liposomes. Therefore, it is urgent to solve the "PEG dilemma". This review focused on the definition, classification of "PEG dilemma", and discussed several possible approaches to overcome "PEG dilemma".
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyethylene Glycols
/
Drug Carriers
/
Chemistry
/
Liposomes
/
Antineoplastic Agents
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Type:
Article
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