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Associations of SUMO4 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients / 药学学报
Acta Pharmaceutica Sinica ; (12): 180-184, 2015.
Article in Chinese | WPRIM | ID: wpr-251798
ABSTRACT
The study aims to investigate the associations of SUMO4 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients. Blood samples and clinical data were collected from 132 renal transplant recipients with tacrolimus treatment. CYP3A5*3 genotypes were detected by PCR-RFLP, and SUMO4 (rs237024, rs237025) genotypes were detected by Sequenom® MassARRAY system. SUMO4 rs237024 and rs237025 genotypes were in complete linkage disequilibrium (D' = 1). The dose-adjusted concentration of tacrolimus in SUMO4 rs237024A-rs237025A (GA-GA +AA-AA) carriers was considerably higher than that in GG-GG carriers (P < 0.05). After stratification by CYP3A5*3 genotypes, SUMO4 rs237024A-rs237025A carriers (GA-GA+AA-AA) had a higher dose-adjusted tacrolimus concentration than that in GG carriers in CYP3A5 expresser (P < 0.05). The results illustrated that SUMO4 rs237024 and rs237025 polymorphisms were associated with tacrolimus concentrations, and the test of these genotypes may be useful for individualized medicine of tacrolimus.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Linkage Disequilibrium / Kidney Transplantation / Tacrolimus / Polymorphism, Single Nucleotide / Small Ubiquitin-Related Modifier Proteins / Therapeutic Uses / Asian People / Cytochrome P-450 CYP3A / Genetics Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Linkage Disequilibrium / Kidney Transplantation / Tacrolimus / Polymorphism, Single Nucleotide / Small Ubiquitin-Related Modifier Proteins / Therapeutic Uses / Asian People / Cytochrome P-450 CYP3A / Genetics Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2015 Type: Article