Roles of the cross talk between MAP kinases and Keap1-Nrf2-ARE signaling pathways in chronic obstructive pulmonary disease / 药学学报
Acta Pharmaceutica Sinica
;
(12): 133-140, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-251805
ABSTRACT
Chronic obstructive pulmonary disease (COPD), a common preventable and treatable disease, is characterized by airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways. Its main pathological manifestations include airway inflammation, mucus hypersecretion, oxidative stress and apoptotic epithelial cells. Recent research suggests that MAP kinases and Keap1-Nrf2-ARE signaling pathway are involved in the pathological process of inflammation and oxidative stress. This review explores the potential role of the cross talk of these signaling pathways in airway inflammation, mucus hypersecretion, oxidative stress and apoptotic epithelial cells. To clarify the roles of cross talk between MAP kinases and Keap1-Nrf2-ARE signaling pathway, we also focus on the drugs related to that in the treatment of COPD, and it provides ideas for more drug research in the treatment of COPD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Respiratory System
/
Signal Transduction
/
Apoptosis
/
Oxidative Stress
/
Mitogen-Activated Protein Kinases
/
Pulmonary Disease, Chronic Obstructive
/
Cell Biology
/
Intracellular Signaling Peptides and Proteins
/
Epithelial Cells
/
NF-E2-Related Factor 2
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Type:
Article
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